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SJTU Research Team Published Research Paper in EBioMedicine

March 10, 2020      Author: Li Yang

On February 27, a research paper titled “Longitudinal Serum Autoantibody Repertoire Profiling Identifies Surgery-Associated Biomarkers in Lung Adenocarcinoma was published online in EBioMedicine, a top international journal. The paper, with great reference value to clinical application of tumor-associated auto-antibody, presents the latest research findings of the cooperation between Tao Shengce’s team from SJTU Center for Systems Biomedicine and Li Hecheng’s team from Rui Jin Hospital, SJTU School of Medicine.

The corresponding authors are Tao Shengce, a researcher of SJTU Center for Systems Biomedicine, and Li Hecheng, Director of Thoracic Surgery in Rui Jin Hospital, SJTU School of Medicine. Doctoral student Li Yang and Li Chengqiang are co-first authors. The research is supported by National Natural Science Foundation of China.


Autoantibodies against tumor associated antigens are highly related to cancer progression. Autoantibodies could serve as indicators of tumor burden, and have the potential to monitor the response of treatment and tumor recurrence. However, how the autoantibody repertoire changes in response to cancer treatment are largely unknown.


Systematical study of the autoantibody repertoire alteration in response to treatment has been barely reported, and to what extent or how prevalent of the autoantibody repertoire alteration is largely unknown. We hypothesize that many more TAAs besides p53 may exist with low prevalence, and one of the best strategies to identify TAAs for recurrence monitoring is to analyze and compare longitudinal samples collected from the same patient. To prove this concept, we collected longitudinal (start from September, 2017, we are still collect- ing) serum samples from 5 patients of lung adenocarcinoma who received surgery. All the samples were then probed on a human prote- ome microarray that contains 20,240 recombinant human proteins [33,34], and the autoantibody profiles were collected for each sample. After comparing the profiles of the samples collected at different time points, especially before and after surgery, from the same individual, we identified several antigens with patterned changes along the time period of serum sample collection. After further study, these antigens may serve as potential markers for alarming the tumor recurrence.